Herpes simplex viruses: mechanisms of DNA replication.

نویسندگان

  • Sandra K Weller
  • Donald M Coen
چکیده

Herpes simplex virus (HSV) encodes seven proteins necessary for viral DNA synthesis-UL9 (origin-binding protein), ICP8 (single-strand DNA [ssDNA]-binding protein), UL30/UL42 (polymerase), and UL5/UL8/UL52 (helicase/primase). It is our intention to provide an up-to-date analysis of our understanding of the structures of these replication proteins and how they function during HSV replication. The potential roles of host repair and recombination proteins will also be discussed.

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عنوان ژورنال:
  • Cold Spring Harbor perspectives in biology

دوره 4 9  شماره 

صفحات  -

تاریخ انتشار 2012